Your perfect partner for in vivo research

Research services

Isoquimen has several years of experience in the performance of different Studies in Beagle dogs, cats and rodents (mice and rats).

Pre-clinical studies

Pharmacokinetic/ Bioequivalence
Bioavailability
Tolerance
Bioactivity/Efficacy
Toxicity (rodents)

-Acute

-MTD

-Repeated doses

Immunological studies

Vaccinal batch release testing

Safety of active and inactive vaccines

Duration of immunity (DOI) Studies

Sensitization against different antigens

Immunization and production of polyclonal antibodies

Nutritional studies

Palatability
Digestibility
Tolerance

Field studies

Planning, design and performance of field Studies for a variety of animal diseases

Added values

Bioanalysis

PK calculation & Statistics

Flexibility to fully coordinate tasks with your research

GLP compliance (if required)

Multiple routes for test item administration

Serial blood sampling in all species

Compound screening

Biomarker analysis

Regulatory Guidelines

ICH: S3A Note for guidance on toxicokinetics: the assessment of systemic exposure in toxicity studies.
VICH Topic GL43 Guideline on target animal safety for veterinary pharmaceuticals products.
ENV/JM/MONO (2000)7 Guidance Document on the recognition, assessment, and use of clinical signs as humane endpoints for experimental animals used in safety evaluation.
EMA/CPMP/ICH/286/1995 December 2009. ICH Guideline M3 (R2) on non-Clinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals.
EMA/CVMP/016/00-Rev.2 April 2011. Guideline on the conduct of bioequivalence studies for veterinary medicinal products
EMA/CVMP/EWP/206024/2011 July 2014. Guideline on the demostration of palatability of veterinary products.